iowaodes

Genetic Evaluation of kids with congenital ocular anomalies in three ecological areas of Nepal

Next generation sequencing reveals a novel pathogenic variant in the ATMgene

 

Introduction: Ataxia telangiectasia (A-T) is a uncommon autosomal recessive multisystemic illness. Sufferers with the A-T syndrome current a broad spectrum of illness phenotypes. The ATM (ataxia telangiectasia mutated) gene, the one causative gene for A-T.

 

Methodology: A affected person of Persian origin presenting with typical A-T was referred to our genetics middle for specialised genetic counseling and testing. Focused next-generation sequencing (NGS) was utilized. Sanger sequencing was used to substantiate the candidate variant. Modeling was carried out utilizing the SWISS-MODEL server.Outcomes: A homozygous stop-gain variant c.829G > T (p.E277*) was discovered within the ATM gene. This variant was confirmed by Sanger sequencing and modeling of native construction and truncated construction was carried out.

 

Conclusion: Thus far, only a few pathogenic variants of the ATM gene have been reported from the Iranian inhabitants. The discovering has implications in molecular diagnostic for A-T in Iran.

iowaodes
iowaodes

 

RIPA Lysis Buffer (Strong)
abx090624-100ml 100 ml
EUR 260.4

RIPA Lysis Buffer (Strong)
HY-K1001 100 mL
EUR 176.4

Pierce Seal Strong Sheets
PCR0632 PK100
EUR 124.8

WB Stripping Solution Strong
05677-65 500ML
EUR 142.8

Pierce Seal Strong Roll610mX78mm
PCR0628 1ROLL
EUR 981.6

PCR Foil Seal Strong Sheets
PCR0528 PK100
EUR 188.4

Tweezers Fine Strong CF Tips
INS5058 EACH
EUR 33.42

Tweezers Flat Strong CF Tips
INS5100 EACH
EUR 39.04

Pierce Seal Strong Sample Roll
PCR0630 1ROLL
EUR 53.01

replacement tip Kit strong thick
INS2090 EACH
EUR 10.35

replacement tip Kit strong point
INS2094 EACH
EUR 10.35

replacement tip Kit strong thick
INS2058 EACH
EUR 10.35

EP Reagent Sodium Hydroxide Sol. Strong
1081404 1L
EUR 170.4

EP Reagent Sodium Hypochlorite Sol. Strong
10816005 500ML
EUR 121.2

Tweezers, Rubis Sturdy, Strong Pointed, 115mm, 4.5€
25046-1 1EA
EUR 48

Genistin
1535-10 each
EUR 196.8

Genistin
N1860-20 20 mg
EUR 268.8
Description: Actions Inactive analog of genistein; useful as a negative control for genistein and other tyrosine kinase inhibitors. Selective inhibitor of mammalian terminal deoxynucleotidyl transferase (TdT),with no measurable effect on mammalian or microbial DNA p

Genistin
HY-N0595 50mg
EUR 170.4

Genistin
GC2802-10 10
EUR 242.4

Genistin
GC2802-100 100
EUR 960.1

Genistin
GC2802-25 25
EUR 382.3

Genistin
GC2802-250 250
EUR 1845.7

Genistin
GC2802-50 50
EUR 577.8

Genistin
TB0370-1000 4X20mg
EUR 321.6

Magnetic Base Support Z w/ Strong Magnet - 34.5mm
M-R-1013161 1 UNIT
EUR 46
Description: Magnetic Base Support Z w/ Strong Magnet - 34.5mm

Magnetic Base Support Z w/ Strong Magnet - 27.5mm
M-R-1015229 1 UNIT
EUR 46
Description: Magnetic Base Support Z w/ Strong Magnet - 27.5mm

Silver Protein for Histology, Strong (not certified)
25108-25 25g
EUR 431
Description: 9015-51-4

Silver Protein for Histology, Strong (not certified)
25108-5 5g
EUR 113
Description: 9015-51-4

UCW5072, Low TOC Strong Base Anion Resin, OH Form
50240-1 1000ml
EUR 192

UCW5072, Low TOC Strong Base Anion Resin, OH Form
50240-250 250ml
EUR 62

Genistin, >99%
BC034-025 25mg
EUR 278.4

Genistin, >99%
BC034-050 50mg
EUR 327.6

Genistin, >99%
BC034-100 100mg
EUR 537.6

Genistin(Genistoside)
E1KS2301 25mg
EUR 390

A510, Type 2 Macroporous Strong Base Rsin, Chloride Form
50223-1 1000ml
EUR 144
Description: 69011-15-0

A510, Type 2 Macroporous Strong Base Resin, Chloride Form
50223-250 250ml
EUR 47
Description: 69011-15-0

Genistin malonate
TB0588-0005 10mg
EUR 886.8

A400, Type 1 Porous Strong Base Anion Resin, Chorlide Form
50218-1 1000ml
EUR 144
Description: 9052-45-3

A400, Type 1 Porous Strong Base Anion Resin, Chorlide Form
50218-250 250ml
EUR 47
Description: 9052-45-3

Optically clear sealing film for qPCR, Strong Bond, for PP plates, 100/pk
MS1000-PCR2 1 each
EUR 145

Foil seals, strong bonding for cold storage (-200 to 110°C) and DMSO, for PP plates, 100/pk
MS1000-F2 1 each
EUR 145

Strongzyme Goat anti Mouse IgG (H+L) (HRP)
43R-1653 1 ml
EUR 763.2
Description: Strongzyme Goat anti-Mouse IgG (H+L) secondary antibody (HRP)

Strongzyme Rabbit anti Goat IgG (H+L) (HRP)
43R-1650 1 ml
EUR 940.8
Description: Strongzyme Rabbit anti Goat IgG (H + L) (HRP) secondary antibody

Strongzyme Goat anti Rabbit IgG (H + L) (HRP)
43R-1652 1 ml
EUR 763.2
Description: Strongzyme Goat anti Rabbit IgG (H + L) secondary antibody (HRP)

QPCR Kit DNA Strongylus vulgaris
MOL8940 EACH
EUR 1004.01

QPCR Kit DNA Strongylus vulgaris
MOL8942 EACH
EUR 1274.27

Strongyloides (IgG/IgM) ELISA Kit (Human) (OKNA00174)
OKNA00174 96 Wells
EUR 505.2
Description: Description of target: Strongyloides is a genus containing some 50 species of obligate gastrointestinal parasites of vertebrates. Strongyloides stercoralis is the scientific name of a human parasitic roundworm causing the disease of strongyloidiasis. Its common name is pinworm in the UK and threadworm in the US. The Strongyloides stercoralis nematode can parasitize humans. The adult parasitic stage lives in tunnels in the mucosa of the small intestine.S. stercoralis can be found in areas with tropical and subtropical climates but cases also occur in temperate area, more frequently in rural areas. S. stercoralis has a very low prevalence in societies where fecal contamination of soil or water is rare. Many people infected are usually asymptomatic at first. Symptoms include dermatitis: swelling, itching, larva currens, and mild hemorrhage at the site where the skin has been penetrated. If the parasite reaches the lungs, the chest may feel as if it is burning, and wheezing and coughing may result, along with pneumonia-like symptoms (Löffler's syndrome). The intestines could eventually be invaded, leading to burning pain, tissue damage, sepsis, and ulcers. In severe cases, edema may result in obstruction of the intestinal tract, as well as loss of peristaltic contractions. Strongyloides infection in immunocompromised individuals (particularly following the administration of steroids, for example following transplant surgery) can result in disseminated strongyloidiasis, in which worms move beyond the confines of the gut into other organs. This is fatal unless antiStrongyloides therapy is given.Locating juvenile larvae, either rhabditiform or filariform, in recent stool samples will confirm the presence of this parasite. Other techniques used include direct fecal smears, culturing fecal samples on agar plates, serodiagnosis through ELISA, and duodenal fumigation.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Reverse Capture Sandwich ELISA ;Sensitivity: Sensitivity is determined as the probability of the assay indicating a positive score in samples with the specific analyte present: 87.9%

StrongZyme Streptavidin-PolyHRP (High Load)
43R-1645 1 mg
EUR 369.6
Description: StrongZyme Streptavidin-PolyHRP conjugate (High Load)

Strontium Oxide
abx186564-500g 500 g
EUR 309.6

Strontium oxide, 99.5%
GX8751-50 50
EUR 585.6

ICP Std Strontium 1000ug/mL in 2-5% HCl
PSR2A3 100ML
EUR 120.12

ICP Std Strontium 1000ug/mL in 2-5% HCl
PSR2B3 250ML
EUR 214.12

ICP Std Strontium 1000ug/mL in 2-5% HCl
PSR2C3 500ML
EUR 265.04

ICP Std Strontium 10000ug/mL in 2-5% HCl
PSR4A3 100ML
EUR 208.9

ICP Std Strontium 10000ug/mL in 2-5% HCl
PSR4B3 250ML
EUR 352.51

Strontium bromide, 99.99%
GX4255-10 10
EUR 325.9

Strontium nitrate, 99.999%
GX6363-50 50
EUR 391

Strontium nitrate, 99.99%
GX1574-50 50
EUR 280.7

Strontium chloride
B7708-50 50 mg
EUR 154.8

Strontium Ranelate
A8526-10 10 mg
EUR 397.2
Description: Strontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Commonly used as an antiosteoporotic.

ICP Std Strontium 100ug/mL in 2-5% HNO3
PSR1A2 100ML
EUR 117.5

ICP Std Strontium 1000ug/mL in 2-5% HNO3
PSR2B2 250ML
EUR 214.12

ICP Std Strontium 1000ug/mL in 2-5% HNO3
PSR2C2 500ML
EUR 261.6

ICP Std Strontium 10000ug/mL in 2-5% HNO3
PSR4A2 100ML
EUR 208.9

ICP Std Strontium 10000ug/mL in 2-5% HNO3
PSR4B2 250ML
EUR 355.12

ICP Std Strontium 10000ug/mL in 3.5% HNO3
PSR4B4-500ML 500ML
EUR 671.08

Strontium Ranelate
HY-17397 500mg
EUR 820.8

Strontium titanate, 99.9%
GX4862-100 100
EUR 340.5

Strontium titanate, 99.9%
GX4862-25 25
EUR 164.5

Strontium fluoride, 99.99%
GX7221-10 10
EUR 134.1

Strontium fluoride, 99.99%
GX7221-25 25
EUR 286.8

Strontium fluoride, 99.99%
GX7221-50 50
EUR 562.1

Strontium fluoride, 99.9%
GX8262-10 10
EUR 116.1

Strontium fluoride, 99.9%
GX8262-50 50
EUR 280.2

Strontium fluoride, 99%
GX3818-250 250
EUR 137.2

Strontium titanate, 99+%
GX1727-250 250
EUR 108.5

Strontium Ranelate
A8526-100 100mg
EUR 126
Description: Calcium Channel activator

Strontium Ranelate
A8526-500 500mg
EUR 437
Description: Calcium Channel activator

AAS Strontium Std 1000ppm in 0.5M HNO3
AASRH 500ML
EUR 246

AAS Strontium Std 10000ppm in 1M HNO3
AASRM 500ML
EUR 356.4

Flame Std Strontium 1000ppm
FISR1 500ML
EUR 190.8

Strontium aluminate, 99+%
GX5543-10 10
EUR 113.1

Strontium aluminate, 99+%
GX5543-50 50
EUR 262.3

Strontium carbonate, 99.999%
GX5614-25 25
EUR 258.5

Strontium zirconate, 99+%
GX8495-250 250
EUR 120.5

Strontium carbonate, 99+%
GX9308-100 100
EUR 129.6

Strontium carbonate, 99+%
GX9308-250 250
EUR 229.6

Strontium molybdate, 99.9%
GX0022-50 50
EUR 189

Strontium tungstate, 99.9%
GX0472-10 10
EUR 101

Strontium tungstate, 99.9%
GX0472-50 50
EUR 233

Strontium carbonate
GK8492-1 1
EUR 50.3

Strontium carbonate
GK8492-250 250
EUR 25.5

Strontium carbonate
GK8492-5 5
EUR 176.1

ICP Standard Strontium 2-5pc
PSR2A2 100ML
EUR 221.95

IC Cation Std Strontium 200ppm in H2O
ICCT43 100ML
EUR 135.6

Strontium Pieces max. 8 mm, under oil, 99.2+%
GX0495-25 25
EUR 1023.2

IC Cation Std Strontium 1000ppm in 0.005% HNO3
ICCB43 500ML
EUR 406.8

IC Cation Std Strontium 1000ppm in 0.005% HNO3
ICCS43 100ML
EUR 157.98

IC Cation Std Strontium 100ppm in 0.005% HNO3
ICCU43 100ML
EUR 137.09

Strontium acetate hydrate, 99+%
GX5175-100 100
EUR 126.5

Strontium chloride hydrate, 99.99+%
GX6973-10 10
EUR 172.7

Strontium nitrate, anhydrous, 98%
GK5693-1KG 1 kg
EUR 98.4

Strontium nitrate, anhydrous, 98%
GK5693-250G 250 g
EUR 60

Strontium nitrate, anhydrous, 98%
GK5693-5KG 5 kg
EUR 255.6

Strontium nitrate, anhydrous, 98%
GK5693-1 1
EUR 51.4

Strontium nitrate, anhydrous, 98%
GK5693-250 250
EUR 19.8

Strontium nitrate, anhydrous, 98%
GK5693-5 5
EUR 182

Strontium titanate Nanopowder, 99.9%
GX7135-1 1
EUR 633.8

Strontium titanate Nanopowder, 99.9%
GX7135-100 100
EUR 192.2

Strontium titanate Nanopowder, 99.9%
GX7135-250 250
EUR 281.9

Strontium titanate Nanopowder, 99.9%
GX7135-50 50
EUR 116.1

Strontium titanate-Nano Powder, 99.8%
GX8434-100 100
EUR 192.2

Strontium titanate-Nano Powder, 99.8%
GX8434-250 250
EUR 373

Strontium titanate-Nano Powder, 99.8%
GX8434-50 50
EUR 116.1

Strontium chloride hexahydrate
GK3876-1KG 1 kg
EUR 132

Strontium chloride hexahydrate
GK3876-500G 500 g
EUR 91.2

Strontium chloride hexahydrate
GK3876-5KG 5 kg
EUR 370.8

Strontium chloride hexahydrate
GK3876-1 1
EUR 79.1

Strontium chloride hexahydrate
GK3876-5 5
EUR 276.9

Strontium chloride hexahydrate
GK3876-500 500
EUR 45.9

Genistein
20-abx184098
  • EUR 326.40
  • EUR 1378.80
  • EUR 594.00
  • 1 g
  • 25 g
  • 5 g

Genistein
1533-10 each
EUR 164.4

Genistein
1533-100 each
EUR 326.4

Genistein, >99%
BC033-101 1g
EUR 278.4

Genistein, >99%
BC033-105 5g
EUR 457.2

Genistein, >99%
BC033-110 10g
EUR 813.6

Genistein
A2198-100 100 mg
EUR 129.6
Description: Phytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPAR? and estrogen receptors and acts as an agonist at GPR30. Also available as part of the MAP

Genistein
A2198-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Phytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPAR? and estrogen receptors and acts as an agonist at GPR30. Also available as part of the MAP

Genistein
20-abx076504
  • EUR 260.40
  • EUR 360.00
  • 10 mg
  • 50 mg

Genistein
GP7710-100MG 100 mg
EUR 180

Genistein
GP7710-10MG 10 mg
EUR 92.4

Genistein
GP7710-250MG 250 mg
EUR 237.6

Genistein
GP7710-50MG 50 mg
EUR 154.8

Genistein
GP7710-5MG 5 mg
EUR 74.4

Genistein
HY-14596 100mg
EUR 142.8

Genistein
40700024-1 10 mg
EUR 29.83

Genistein
40700024-2 25 mg
EUR 50.93

Genistein
40700024-3 100 mg
EUR 117.63

Genistein
GP7710-10 10
EUR 74.7

Genistein
GP7710-100 100
EUR 118.7

Genistein
GP7710-250 250
EUR 180.9

Genistein
GP7710-5 5
EUR 31.7

Genistein
GP7710-50 50
EUR 116.1

Genistein
TB0320-0500 8XX25mg
EUR 328.8

Genistein [CAS# 446-72-0]
G-6055 1 g
EUR 59

Strontium ranelate heptahydrate
20-abx184380
  • EUR 444.00
  • EUR 944.40
  • 1 g
  • 500 g

Strontium hydroxide, octahydrate, 99+%
GX1288-1 1
EUR 101

Strontium hydroxide, octahydrate, 99+%
GX1288-500 500
EUR 84.4

Genistein 10mM
TG4160 0.25ml
EUR 187.2

Assurance Grade Strontium for AA and ICP 1000 ug/mL (1000 PPM) 500mL in 2% HCl
PLSR1-2X 500ML
EUR 158.4

Assurance Grade Strontium for AA and ICP 1000 ug/mL (1000 PPM) 30mL in 2% HNO3
PLSR2-2M 30ML
EUR 34.8

Assurance Grade Strontium for AA and ICP 1000 ug/mL (1000 PPM) 250mL in 2% HNO3
PLSR2-2T 250ML
EUR 111.6

Assurance Grade Strontium for AA and ICP 1000 ug/mL (1000 PPM) 500mL in 2% HNO3
PLSR2-2X 500ML
EUR 144

Assurance Grade Strontium for AA and ICP 1000 ug/mL (1000 PPM) 125mL in 2% HNO3
PLSR2-2Y01 125ML
EUR 64.8

Assurance Grade Strontium for AA and ICP 10000 ug/mL (10000 PPM) 500mL in 5% HNO3
PLSR2-3X 500ML
EUR 255.6

Assurance Grade Strontium for AA and ICP 10000 ug/mL (10000 PPM) 125mL in 5% HNO3
PLSR2-3Y 125ML
EUR 108

Strontium Chloride Diluting Solution
SRCL201 1L
EUR 72

Claritas PPT Grade Strontium for ICP-MS 1 ug/mL (1 PPM) 125mL in 2% HNO3
CLSR2-1BY 125ML
EUR 103.2

Kinesis Hollow Cathode Lamp Strontium 37mm Std
CHR6011 EACH
EUR 334.23

Strontium chloride hexahydrate, 99%, ACS grade
GX3549-500G 500 g
EUR 122.4

Strontium chloride hexahydrate, 99%, ACS grade
GX3549-500 500
EUR 71.1

Strontium Pieces max. 20 mm, under argon, coated with oil, Ba max. 1%, 99%
GX0588-100 100
EUR 550.7

Genistein Solution
40140050-1 1 mL
EUR 43.46

Kinesis Hollow Cathode Lamp Strontium 37mm unicam
CHR6015 EACH
EUR 385.15

Kinesis Hollow Cathode Lamp Strontium 37mm Varian
CHR6017 EACH
EUR 385.15

Familial dilated cardiomyopathy brought on by a novel variant within the Lamin A/C gene: a case report

Background: Familial dilated cardiomyopathy (FDCM) is mostly inherited as an autosomal dominant trait. The Lamin A/C (LMNA) gene variants have been recognized to be related to DCM, conductive system problems, kind 2 Emery-Dreifuss muscular dystrophy and a number of other different problems. Right here, we reported a novel variant within the LMNA gene that is likely to be associated to FDCM.

 

Case presentation: A 30-year-old younger man was hospitalized for chest tightness, excessive fatigue, palpitation and impaired exercise tolerance. He had scientific traits together with cardiac dilatation, atrial tachyarrhythmia, extreme conductive system problems, and dyskinesia of each higher limbs and the neck. Genetic sequence evaluation indicated that the affected person carried a novel c.1325 T>C heterozygous LMNA gene variant. Catheter ablation and cardiac resynchronization remedy with pacing perform (CRT-P) have been carried out to deal with the arrhythmia.

 

Conclusion: The variant c.1325 T>C is a novel variant within the LMNA gene that has not been beforehand reported. Younger sufferers with DCM, conductive system problems and skeletal myopathy ought to be alert to the potential for LMNA gene variant. Cardiac resynchronization remedy (CRT) could also be an affordable selection for affected person carrying a LMNA gene variant with third-degree atrioventricular block even when the left ventricular ejection fraction is preserved with the intention to stop the deterioration of cardiac perform brought on by proper ventricular pacing dependency.

 

Genetic evaluation of kids with congenital ocular anomalies in three ecological areas of Nepal: a section II of Nepal pediatric ocular illnesses research

 

Background: Genetic eye illnesses represent a big and heterogeneous group of childhood ocular morbidity. Particular person illnesses could trigger a number of structural anomalies and developmental options. Nepal Pediatric Ocular Illness Research (NPODS) was a population-based epidemiological research carried out throughout three ecological areas of Nepal to find out the prevalence and etiology of childhood ocular morbidity and blindness. In Part II of this research, genetic evaluation was carried out for kids who have been discovered to have congenital ocular anomalies.

 

Methodology: It was a cross sectional descriptive research. A complete of 10,270 youngsters throughout three totally different ecological areas in Nepal (Low lands, hills, and mountains) underwent ocular examinations in NPODS. Out of 374 (3.6%) of kids with ocular abnormalities, 30 have been considered congenital in nature. Focused genetic evaluation, together with genotyping for genes particular to presenting phenotype, was carried out for 25 youngsters utilizing serum samples.

 

Outcomes: Out of 25 youngsters, 18 had significant genetic outcomes. Evaluation revealed one missense alteration G12411T of Zinc Finger Homeobox 4 (ZFHX4) gene in a single participant amongst 10 with congenital ptosis and one other missense variation T > C P. Y374 C of Signaling Receptor and Transporter Retinol 6 (STRA6) gene in a single participant amongst Three with microphthalmos.

 

Conclusion: The research is first of its sort from Nepal and mutant genes have been distinctive to Nepalese Inhabitants. Additional evaluation of genetic components is essential to higher perceive genetic affiliation with ocular illnesses and situations. This helps additional in genetic counseling and doubtless gene remedy to forestall blindness from these situations.

 

Doxorubicin hydrochloride
ADC-P-014 unit Ask for price

Doxorubicin hydrochloride
GA4969-100MG 100 mg
EUR 217.2

Doxorubicin hydrochloride
GA4969-10MG 10 mg
EUR 93.6

Doxorubicin hydrochloride
GA4969-25MG 25 mg
EUR 117.6

Doxorubicin hydrochloride
GA4969-50MG 50 mg
EUR 151.2

Doxorubicin (hydrochloride)
HY-15142 100mg
EUR 176.4

Doxorubicin Hydrochloride
40410004-1 10 mg
EUR 136.34

Doxorubicin Hydrochloride
40410004-2 25 mg
EUR 273.17

Doxorubicin hydrochloride
TNC00267 20mg Ask for price

Doxorubicin hydrochloride, 98%
GP9056-100 100
EUR 140.2

Doxorubicin hydrochloride, 98%
GP9056-25 25
EUR 56.1

Doxorubicin hydrochloride USP
D005-10MG 10 mg
EUR 199.2

Doxorubicin hydrochloride USP
D005-25MG 25 mg
EUR 361.2

Doxorubicin hydrochloride, USP grade
GA4969-10 10
EUR 47.4

Doxorubicin hydrochloride, USP grade
GA4969-100 100
EUR 150.4

Doxorubicin hydrochloride, USP grade
GA4969-25 25
EUR 67.2

Doxorubicin hydrochloride, USP grade
GA4969-50 50
EUR 95

Doxorubicin Hydrochloride (Autophagy inducer)
SIH-390-10MG 10 mg
EUR 231.6
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM)..

Doxorubicin Hydrochloride (Autophagy inducer)
SIH-390-50MG 50 mg
EUR 634.8
Description: The substance Doxorubicin Hydrochloride is a autophagy inducer. It is synthetically produced and has a purity of >98%. The pure substance is red solid which is soluble in water (50 mM)..

Doxorubicin
abx188695-1g 1 g
EUR 560.4

Doxorubicin
A3966-10 10 mg
EUR 129.6
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin
A3966-100 100 mg
EUR 282
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin
A3966-25 25 mg
EUR 157.2
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin
A3966-5.1 10 mM (in 1mL DMSO)
EUR 157.2
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin
A3966-S Evaluation Sample
EUR 97.2
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin
ADC-P-013 unit Ask for price

Doxorubicin
D063-100MG 100 mg
EUR 1261.2

Doxorubicin
D063-25MG 25 mg
EUR 386.4

Doxorubicin
HY-15142A 100mg
EUR 258

Doxorubicin
D063-5MG 5 mg
EUR 460.82
Description: C27H29NO11

Doxorubicin HCl
20-abx184016
  • EUR 895.20
  • EUR 1779.60
  • 1 g
  • 5 g

Doxorubicin 10mM
TG4120 0.25ml
EUR 187.2

Doxorubicin HCl, 100mg
R2531-100mg each
EUR 1560

Doxorubicin HCl, 10mg
R2531-10mg each
EUR 236.4

Doxorubicin HCl, 100mg
R2531 100mg
EUR 1080.79

Adriamycin (Doxorubicin)
E1KS1208 10mg
EUR 490.8

Doxorubicin (Adriamycin) HCl
A1832-10 10 mg
EUR 150
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin (Adriamycin) HCl
A1832-100 100 mg
EUR 560.4
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin (Adriamycin) HCl
A1832-25 25 mg
EUR 226.8
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

Doxorubicin (Adriamycin) HCl
A1832-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Doxorubicin is a semi-synthesized anticancer agent derived from bacterial culture. [1] It is an anthracycline antibiotic. It is been widely used in blood cancers, solid tumors and sarcomas.

PEGylated Liposomal Doxorubicin- 2 mg
PHPC002DX 2 mg
EUR 140.62
Description: This product includes 1 ml of liposomal doxorubicin at concentrations of 2 mg/ml doxorubicin and 16 mg/ml of lipids.

PEGylated Liposomal Doxorubicin- 20 mg
PHPC020DX 20 mg
EUR 358.62
Description: This product includes 10 ml of liposomal doxorubicin at concentrations of 2 mg/ml doxorubicin and 16 mg/ml of lipids.

Human Doxorubicin-Stimulated HeLa Whole Cell Lysate
IHUHELADTLW500UG each
EUR 327
Description: Human Doxorubicin-Stimulated HeLa Whole Cell Lysate

Erlotinib, Hydrochloride Salt
1588-100 each
EUR 202.8

Erlotinib, Hydrochloride Salt
1588-1000 each
EUR 477.6

Human Doxorubicin-Stimulated HeLa Nuclear Extract Lysate
IHUHELADTLN200UG each
EUR 427
Description: Human Doxorubicin-Stimulated HeLa Nuclear Extract Lysate

Erlotinib, Hydrochloride Salt, >99%
BC026-101 1g
EUR 327.6

Erlotinib, Hydrochloride Salt, >99%
BC026-102 2g
EUR 465.6

Erlotinib, Hydrochloride Salt, >99%
BC026-105 5g
EUR 684

17-DMAG, Hydrochloride Salt, >98%
BC024-001 1mg
EUR 213.6

17-DMAG, Hydrochloride Salt, >98%
BC024-005 5mg
EUR 343.2

17-DMAG, Hydrochloride Salt, >98%
BC024-010 10mg
EUR 489.6

17-DMAG, Hydrochloride Salt, >98%
BC024-025 25mg Ask for price

17-DMAG, Hydrochloride Salt, >99%
BC024-100 100mg Ask for price

17-DMAG, Hydrochloride Salt, >99%
BC024-101 1g Ask for price

17-DMAG, Hydrochloride Salt, >99%
BC024-250 250mg Ask for price

OSU-03012, Hydrochloride Salt, >98%
BC061-005 5mg
EUR 375.6

OSU-03012, Hydrochloride Salt, >98%
BC061-025 25mg
EUR 634.8

Human HeLa (Cervix Adenocarcinoma) Whole Cell Lysate - Doxorubicin Stimulated
HCL-2010 100ug
EUR 255.6

Alectinib, Hydrochloride Salt [CAS# 1256589-74-8]
A-2311 25 mg
EUR 49

Erlotinib, Hydrochloride Salt [CAS# 183319-69-9]
E-4007 500 mg
EUR 37

Pazopanib, Hydrochloride Salt [CAS# 635702-64-6]
P-6755 25 mg
EUR 46

Human HeLa (Cervix Adenocarcinoma) Cell Nuclear Extract - Doxorubicin Stimulated
HCL-2004 100ug
EUR 270

Doxorubicin.HCl
1527-5 each
EUR 183.6

Epirubicin, Hydrochloride Salt [CAS# 56390-09-1]
E-8000 5 mg
EUR 37

Fingolimod, Hydrochloride Salt [CAS# 162359-56-0]
F-4633 100 mg
EUR 41

Gemcitabine, Hydrochloride Salt [CAS# 122111-03-9]
G-4177 100 mg
EUR 39

Palbociclib, Hydrochloride Salt [CAS# 827022-32-2]
P-7788 50 mg
EUR 39

Irinotecan, Hydrochloride Salt, Trihydrate [CAS# 136572-09-3]
I-4122 100 mg
EUR 39

L-Leucine 7-amido-4-methylcoumarin hydrochloride salt
GC8248-100 100
EUR 143.7

L-Leucine 7-amido-4-methylcoumarin hydrochloride salt
GC8248-25 25
EUR 57.8

Doxepin (hydrochloride)
C4153-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine.

Doxepin (hydrochloride)
C4153-5000 5 g
EUR 201.6
Description: Doxepin, a tricyclic antidepressant, is a potent histamine H1 antagonist [1]. The histamine receptors belong to a family of G protein?coupled receptors activated by their primary endogenous ligand histamine.

Doxepin (Hydrochloride)
HY-B0725 500mg
EUR 129.6

Doxapram hydrochloride
GP6685-100 100
EUR 201.9

Doxycycline Hydrochloride
D065-25MG 25mg
EUR 410.4

Doxycycline Hydrochloride
D065-5MG 5mg
EUR 142.8

Doxycycline hydrochloride
GA4252-1G 1 g
EUR 99.6

Doxycycline hydrochloride
GA4252-500MG 500 mg
EUR 74.4

Doxycycline (hydrochloride)
HY-N0565A 1g
EUR 142.8

Doxycycline hydrochloride
GA4252-1 1
EUR 53.1

Doxycycline hydrochloride
GA4252-500 500
EUR 31.7

Doxycycline Hydrochloride
40410005-1 10 g
EUR 92.3

Doxycycline Hydrochloride
40410005-2 25 g
EUR 181.73

Doxapram (hydrochloride hydrate)
HY-B0551A 10mM/1mL
EUR 206.4

(±)-Salsolinol (hydrochloride)
C4364-500 500 mg
EUR 369.6
Description: (±)-Salsolinol targets depolarize dopamineric neurons. Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions.

2‐AMINO ACETAMIDE HYDROCHLORIDE (GLYCINAMIDE HYDROCHLORIDE)
101003 each Ask for price

DOI hydrochloride
B5321-10 10 mg
EUR 205.2

DOI hydrochloride
B5321-5 5 mg
EUR 141.6

DOI hydrochloride
B5321-50 50 mg
EUR 714

DOB hydrochloride
B5344-1 1 mg
EUR 141.6

Q94 hydrochloride
B5705-10 10 mg
EUR 350.4

Q94 hydrochloride
B5705-50 50 mg
EUR 1264.8

GMQ hydrochloride
B5793-10 10 mg
EUR 212.4

GMQ hydrochloride
B5793-50 50 mg
EUR 711.6

AMT hydrochloride
B6480-10 10 mg
EUR 205.2

AMT hydrochloride
B6480-100 100 mg
EUR 1036.8

AMT hydrochloride
B6480-5 5 mg
EUR 141.6

AMT hydrochloride
B6480-50 50 mg
EUR 673.2

BEC (hydrochloride)
HY-19548A 25mg
EUR 570

EDC hydrochloride
GP0849-100G 100 g
EUR 141.6

EDC hydrochloride
GP0849-250G 250 g
EUR 237.6

EDC hydrochloride
GP0849-25G 25 g
EUR 84

EDC hydrochloride
GP0849-5G 5 g
EUR 55.2

SAG (hydrochloride)
HY-12848B 10mg
EUR 321.6

EDC hydrochloride
GP0849-100 100
EUR 87.1

EDC hydrochloride
GP0849-25 25
EUR 39.4

EDC hydrochloride
GP0849-250 250
EUR 166

EDC hydrochloride
GP0849-5 5
EUR 15.9

EDC Hydrochloride
40500004-1 5 g
EUR 84.12

EDC Hydrochloride
40500004-2 10 g
EUR 116.56

AMTB hydrochloride
B2978-25 25 mg
EUR 812.4

AMTB hydrochloride
B2978-5 5 mg
EUR 247.2

MPEP hydrochloride
B1151-10 each
EUR 222

MPEP hydrochloride
B1151-50 each
EUR 705.6

S1RA hydrochloride
B1180-10 10 mg
EUR 1144.8
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-100 100 mg
EUR 4620
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-5 5 mg
EUR 819.6
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-5.1 10 mM (in 1mL DMSO)
EUR 895.2
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

S1RA hydrochloride
B1180-50 50 mg
EUR 3316.8
Description: S1RA hydrochloride is a potent and selective antagonist of ?1 receptor (?1R) with Ki value of 17nM [1].S1RA is the first ?1 receptor antagonist with potent antinociceptive activities in various pain models.

THZ1 Hydrochloride
B4736-10 10 mg
EUR 268.8
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-25 25 mg
EUR 477.6
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-5 5 mg
EUR 170.4
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

THZ1 Hydrochloride
B4736-5.1 10 mM (in 1mL DMSO)
EUR 205.2
Description: THZ1 is a covalent inhibitor of CDK7 with IC50 value of 3.2nM [1].THZ1 covalently modifies CDK7 by targeting C312 residue outside of the kinase domain, providing an unanticipated means of achieving covalent selectivity.

EHNA hydrochloride
2265-25 each
EUR 339.6

EHNA hydrochloride
2265-5 each
EUR 138

TAME Hydrochloride
2050-100 each
EUR 151.2

TAME Hydrochloride
2050-1000 each
EUR 574.8

TAME Hydrochloride
2050-500 each
EUR 405.6

DMCM hydrochloride
B7268-10 10 mg
EUR 385.2

DMCM hydrochloride
B7268-100 100 mg
EUR 2210.4

DMCM hydrochloride
B7268-25 25 mg
EUR 776.4

DMCM hydrochloride
B7268-5 5 mg
EUR 277.2

DMCM hydrochloride
B7268-5.1 10 mM (in 1mL H2O)
EUR 297.6

DMCM hydrochloride
B7268-50 50 mg
EUR 1363.2

TRIS hydrochloride
B7299-500000 500 g
EUR 309.6

AMTB hydrochloride
B7559-10 10 mg
EUR 459.6

AMTB hydrochloride
B7559-50 50 mg
EUR 1746

MPEP Hydrochloride
A3633-10 10 mg
EUR 142.8
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system.

MPEP Hydrochloride
A3633-50 50 mg
EUR 379.2
Description: IC50: 36 nMMPEP is a potent, selective and systemically active mGlu5 receptor antagonist. Metabotropic glutamate (mGlu) receptors are a of G-protein-coupled receptor family linked to multiple second messengers and modulation of ion channel functions in the nervous system.

MPTP hydrochloride
A3634-10 10 mg
EUR 162
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1].

MPTP hydrochloride
A3634-50 50 mg
EUR 344.4
Description: IC50 Value: 53uM?inhibited the nerve-evoked twitches of phrenic nerve-hemidiaphragm preparations from ICR mice? . MPTP HCl (Sigma-Chem.) induced reduction in the DOPAC HVA/dopamine (DA) ratio and increase in striatal ascorbate (AS) oxidation in rats [1].

MTEP hydrochloride
A3636-10 10 mg
EUR 205.2
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

MTEP hydrochloride
A3636-5 5 mg
EUR 153.6
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

MTEP hydrochloride
A3636-50 50 mg
EUR 686.4
Description: IC50: 5 nMMTEP is a selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonist.The mGluRs are classified into three groups: group I (mGluR1 and 5), group II (mGluR2 and 3) and group III (mGluR4, 6, 7 and 8).

PJ34 hydrochloride
A4159-10 10 mg
EUR 142.8
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-5 5 mg
EUR 129.6
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-5.1 10 mM (in 1mL DMSO)
EUR 150
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-50 50 mg
EUR 296.4
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

PJ34 hydrochloride
A4159-S Evaluation Sample
EUR 97.2
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM.

TCEP hydrochloride
B6055-10000 10 g
EUR 338.4
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride
B6055-2000 2 g
EUR 150
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

TCEP hydrochloride
B6055-50000 50 g
EUR 1243.2
Description: Tris(2-carboxyethyl)phosphine hydrochloride (TCEP HCL) is a water soluble strong reducing agent that cleave disulfide bonds. It is a non-thiol and non-volatile solid.

HEAT hydrochloride
B6339-10 10 mg
EUR 321.6

HEAT hydrochloride
B6339-50 50 mg
EUR 1167.6

THIP hydrochloride
B6460-100 100 mg
EUR 358.8

THIP hydrochloride
B6460-25 25 mg
EUR 174

THIP hydrochloride
B6460-50 50 mg
EUR 243.6

EHNA hydrochloride
B6662-10 10 mg
EUR 145.2

EHNA hydrochloride
B6662-25 25 mg
EUR 262.8

N20C hydrochloride
B6980-10 10 mg
EUR 340.8

N20C hydrochloride
B6980-50 50 mg
EUR 1245.6

TMPH hydrochloride
B7053-10 10 mg
EUR 321.6

TMPH hydrochloride
B7053-50 50 mg
EUR 1167.6

DAPI (hydrochloride)
C3362-10 10 mg
EUR 146.4

DAPI (hydrochloride)
C3362-25 25 mg
EUR 240

DAPI (hydrochloride)
C3362-5 5 mg
EUR 111.6

AD57 (hydrochloride)
C3080-1 1 mg
EUR 141.6
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)
C3080-10 10 mg
EUR 714
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

AD57 (hydrochloride)
C3080-5 5 mg
EUR 428.4
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer.

MMAD hydrochloride
ADC-P-019 unit Ask for price

MMAF Hydrochloride
ADC-P-021 unit Ask for price

THZ1 hydrochloride
9544-25 each
EUR 1227.6

THZ1 hydrochloride
9544-5 each
EUR 366

TRIS hydrochloride
GB4431-100G 100 g
EUR 64.8

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